Autoantibodies Definition,Examples,Diseases and [Flashcards]

Autoantibodies Definitions:

  • an immunoglobulin produced by a person that recognizes an antigen on that person’s own tissues.
  • An antibody derived from the immune system, which then acts against body tissues or constituents.
  • Antibody occurring in response to antigenic constituents of the host’s tissue, and which reacts with the inciting tissuecomponent.
  • an antibody formed in response to, and reacting against, an antigenic constituent of the individual’s own tissues.

Autoantibodies examples with resulting diseases

1. Antiphospholipid syndrome >>

  • Anti-beta2 glycoprotein: increased thrombosis (arterial or venous) or spontaneous abortion from placental clots, strokes, hepatic vein clots
  • lupus anticoagulant = hypercoagulation!
  • anticardiolipin

2. Autoimmune hepatitis type 1 >> Anti-smooth muscle

3. Bullous pemphigoid>>Anti-hemidesmosome

Bullous pemphigoid>>Anti-hemidesmosome

4.Celiac disease>>

  • IgA anti-endomysial
  • IgA anti-tissue transglutaminase

5. Diffuse Scleroderma >> anti-Scl-70 antibody (anti-DNA topoisomerase)

6. Drug-induced lupus>> Anti-histone

7. Goodpasture syndrome>>Anti-glomerular basement membraneGoodpasture syndrome

8.Granulomatosis with polyangiitis >> PR3-ANCA / c-ANCA

8.Granulomatosis with polyangiitis >> PR3-ANCA / c-ANCA

9. Graves disease>> Anti-TSH receptor (activates it)

9.Graves disease>> Anti-TSH receptor (activates it)

10. Hashimoto thyroiditis >>

  • Antimicrosomal
  • Antithyroglobulin
  • Anti-thyroid peroxidase (TPO)
  •  Hashimoto thyroiditis >>

11.Lambert-Eaton myasthenic syndrome > Anti-presynaptic voltage-gated calcium channel

Lambert-Eaton myasthenic syndrome >

12. Limited scleroderma (CREST syndrome)>> Anticentromere

 Limited scleroderma (CREST syndrome)

13.lupus >>

  • Anticardiolipin
  • Lupus anticoagulant
  • SPECIFIC: Anti-smith and anti-dsDNA abs
  • Anti nuclear bodies
  • Anti-histones: Rx-induced

 

13. Mixed connective tissue disease >> Anti-U1 RNP (ribonucleoprotein)

14. Myasthenia gravis>>Anti-ACh receptor (blocks receptor)

. Myasthenia gravis>>

15. Often associated with SLE (nonspecific)>> Antinuclear (ANA)

16. Pemphigus vulgaris>> Anti-desmoglein

Pemphigus vulgaris>>

17. Pernicious anemia>>Antiparietal cell ,,Anti-intrinsic factor

Pernicious anemia>>Antiparietal cell ,,Anti-intrinsic factor

18. Polymyositis ,,Dermatomyositis >>

  • Antisynthetase (anti-Jo-1)
  • Anti-SRP
  • Anti-helicase (anti-Mi-2)
  • Polymyositis ,,Dermatomyositis >> Antisynthetase (anti-Jo-1) Anti-SRP Anti-helicase (anti-Mi-2)

19. Primary biliary cirrhosis >> Antimitochondrial

19. Primary biliary cirrhosis >> Antimitochondrial

20.Primary membranous nephropathy>>

  • Antiphospholipase A2 receptor
  • 85% of membranous nephropathy

Primary membranous nephropathy>> Antiphospholipase A2 receptor 85% of membranous nephropathy

21. Rheumatoid arthritis>>

  • Rheumatoid factor (IgM against IgG Fc region)
  • Anti-CCP (more specific)
  • Rheumatoid arthritis>> Rheumatoid factor (IgM against IgG Fc region) Anti-CCP (more specific)

22. Scleroderma (diffuse) >> Anti-Scl-70 (anti-DNA topoisomerase I)

 Scleroderma (diffuse) >> Anti-Scl-70 (anti-DNA topoisomerase I)

23. Sjogren’s syndrome>>

  • Anti-SS-A (Anti-Ro)
  • Anti-SS-B (Anti-La)
  • Sjogren's syndrome>> Anti-SS-A (Anti-Ro) Anti-SS-B (Anti-La)

24. SLE>>>

  • Anti-dsDNA
  • Anti-smith
  •  SLE>>> Anti-dsDNA Anti-smith

25.Type 1 DM>>

  • Anti-glutamic acid decarboxylase (GAD)
  • Anti-islet cell cytoplasmic antibodies
  • Type 1 DM>> Anti-glutamic acid decarboxylase (GAD) Anti-islet cell cytoplasmic antibodies

26. VASCULITIS>> MPO-ANCA / p-ANCA

  • Microscopic polyangiitis
  • Eosinophilic granulomatosis with polyangiitis
  • Ulcerative colitis
  • VASCULITIS>> MPO-ANCA / p-ANCA Microscopic polyangiitis Eosinophilic granulomatosis with polyangiitis Ulcerative colitis

27. Wegener’s granulomatosis>>

  • c-ANCA
  • vasculitis: necrotizing granulomas of lung & necrotizing glomerulonephritis

 Flash cards for Autoantibodies:

 

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